Resources

Discover articles, research, and published papers exploring the science, clinical applications, and evolving role of therapeutic apheresis in complex and chronic conditions.

Apheresis-Related Published Research

Lipoprotein Apheresis for Lipoprotein(a)-Associated Cardiovascular Disease Prospective 5 Years of Follow-Up and Apolipoprotein(a) Characterization

July 2026

Lipoprotein Apheresis for Lipoprotein(a)-Associated Cardiovascular Disease Prospective 5 Years of Follow-Up and Apolipoprotein(a) Characterization

Results of 5 years of prospective follow-up confirm that LA has a lasting effect on prevention of cardiovascular events in patients with Lp(a)-HLP. Patients clinically selected by progressive cardiovascular disease were characterized by a highly frequent expression of small apo(a) isoforms. Only Lp(a) concentration seemed to comprehensively reflect Lp(a)-associated cardiovascular risk, however.

Eberhard Roeseler, Ulrich Julius, Franz Heigl, Ralf Spitthoever, Dennis Heutling, Paul Breitenberger, Josef Leebmann, Walter Lehmacher, Pia R. Kamstrup, Børge G. Nordestgaard, Winfried Maerz, Asma Noureen, Konrad Schmidt, Florian Kronenberg, Andreas Heibges, Reinhard Klingel, for the Pro(a)LiFe-Study Group

Most significant reduction of cardiovascular events in patients undergoing lipoproteinapheresis due to raised Lp(a) levels e A multicenter observational study

2017

Most significant reduction of cardiovascular events in patients undergoing lipoproteinapheresis due to raised Lp(a) levels e A multicenter observational study

In conclusion to date LA is the only highly efficacious and safe treatment option for patients with marked elevation of Lp(a) (>600 mg/l or > 120 nmol/l) and progressive CVD. This study indicates that patients with raised Lp(a) appear to be at the highest CV risk before LA and benefit most from LA with the most marked CV event reduction rates in all vessel beds, compared to patients with isolated hypercholesterolemia. Further prospective studies to confirm these data are warranted

U. Schatz, S. Tselmin, G. Mu¨ller, U. Julius, B. Hohenstein, S. Fischer, S.R. Bornstein

Beyond lipids: Systemic effects of lipoprotein apheresis

January 2026

Beyond lipids: Systemic effects of lipoprotein apheresis

The pleiotropic effects of LDL apheresis represent a fascinating convergence of lipid metabolism with inflammatory and hemostatic pathways. LA not only subtracts atherogenic lipoproteins but also acutely quiets inflammation, improves endothelial performance, thins the blood, and moderates immune activation

Menatalla Nadim, Yamac Akgun

Lipoprotein(a) apheresis in patients with peripheral arterial disease: rationale and clinical results

Published online: 15 March 2019

Lipoprotein(a) apheresis in patients with peripheral arterial disease: rationale and clinical results

Patients with symptomatic peripheral arterial disease (PAD) are at a very high risk of cardiovascular morbidity and mortality. Elevated lipoprotein(a) levels have been shown to be a risk factor for coronary artery disease (CAD) and stroke.

Norbert Weiss, Ulrich Julius

Lipoprotein apheresis in patients with peripheral artery disease and lipoprotein(a)-hyperlipoproteinemia: 2-year follow-up of a prospective single center study

November 2017

Lipoprotein apheresis in patients with peripheral artery disease and lipoprotein(a)-hyperlipoproteinemia: 2-year follow-up of a prospective single center study

As early as 1 month after initiation of LA, all investigated parameters had improved significantly compared to baseline. This improvement was further substantiated under LA throughout the entire follow-up period.

Wolfram C. Poller, Axel Berger, Henryk Dreger, Stanislao Morgera, Kathrin EnkeMelzer